c-KIT and c-KIT ligand (SCF) in synovial sarcoma (SS): an mRNA expression analysis in 23 cases
نویسندگان
چکیده
منابع مشابه
W-sash affects positive and negative elements controlling c-kit expression: ectopic c-kit expression at sites of kit-ligand expression affects melanogenesis.
The receptor tyrosine kinase c-kit and its cognate ligand KL are encoded at the white spotting (W) and steel (Sl) loci of the mouse, respectively. Mutations at both the W and the Sl locus cause deficiencies in gametogenesis, melanogenesis and hematopoiesis (erythrocytes and mast cells). The W-sash mutation differs from most W mutations in that it affects primarily mast cells and melanogenesis b...
متن کاملTranscription Factor SCL Is Required for c-kit Expression and c-Kit Function in Hemopoietic Cells
In normal hemopoietic cells that are dependent on specific growth factors for cell survival, the expression of the basic helix-loop-helix transcription factor SCL/Tal1 correlates with that of c-Kit, the receptor for Steel factor (SF) or stem cell factor. To address the possibility that SCL may function upstream of c-kit, we sought to modulate endogenous SCL function in the CD34(+) hemopoietic c...
متن کاملComparative analysis of c-kit gene expression and c-Kit immunoreactivity in horses with and without obstructive intestinal disease.
Previous immunohistochemical studies targeting the receptor tyrosine kinase (c-Kit) have demonstrated an apparent reduction in the number of gastrointestinal pacemaker cells--the interstitial cells of Cajal (ICC)--in horses with intestinal motility disorders. This study compared the level of transcription of the c-kit gene encoding this receptor in horses with and without such motility disorder...
متن کاملRegulation of ovarian folliculogenesis by Kit Ligand and the c-Kit system in mammals
The system comprised of Kit Ligand (KL) and its receptor c-Kit has proven to play a role in normal female reproduction and fertility in mammals. Gene expression studies have revealed that biological activities of ligands and receptors of the KL/c-Kit system are important in controlling apoptosis and cellular proliferation in reproductive tissues. Collectively, these studies have provided a bett...
متن کاملA promising hypothesis of c-KIT methylation/ expression paradox in c-KIT (+) squamous cell carcinoma of uterine cervix ----- CTCF transcriptional repressor regulates c-KIT proto-oncogene expression
We recently reported one interesting case showing mutation-free c-KIT proto-oncogene overexpression and paradoxical hypermethylation in 54 cases of primary squamous cell carcinoma of uterine cervix (SCC). However, its molecular mechanisms still remain unknown. We propose the hypothesis that increased methylation at the CpG islands on the promoter near the first exon region might interfere with ...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 2001
ISSN: 0007-0920,1532-1827
DOI: 10.1054/bjoc.2001.1935